{"id":639,"global_id":"washingtonengineer.org?id=639","global_id_lineage":["washingtonengineer.org?id=639"],"author":"6","status":"publish","date":"2023-05-07 13:45:00","date_utc":"2023-05-07 20:45:00","modified":"2023-06-15 21:01:10","modified_utc":"2023-06-16 04:01:10","url":"https:\/\/washingtonengineer.org\/wspe_event\/non-destructive-3d-pathology-and-analysis-for-precision-medicine\/","rest_url":"https:\/\/washingtonengineer.org\/wp-json\/tribe\/events\/v1\/events\/639","title":"Non-destructive 3D Pathology and Analysis for Precision Medicine","description":"<div  class=\"tribe-events-schedule tribe-clearfix\" >\n\t<h2 class=\"tribe-events-schedule__datetime\">\n\t\t<span class=\"tribe-events-schedule__date tribe-events-schedule__date--start\">\n\t\t\t\t\t<\/span>\n\n\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--date\">\n\t\t\t\t @ \t\t\t<\/span>\n\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--start\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\n\t\t\t<\/h2>\n<\/div>\n\n\n\n<p>The current diagnostic \u201cgold standard\u201d in medicine is histopathology, a centuries-old process in which tissue biopsies from patients are preserved, embedded in wax blocks, cut into thin tissue sections, mounted on glass slides, and stained so that they can be viewed with analog microscopes similar to what are used in high school biology classes.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"epyt-video-wrapper\"><div  id=\"_ytid_75854\"  width=\"800\" height=\"450\"  data-origwidth=\"800\" data-origheight=\"450\" data-facadesrc=\"https:\/\/www.youtube.com\/embed\/Gsz_GMzoWgY?enablejsapi=1&#038;autoplay=0&#038;cc_load_policy=0&#038;cc_lang_pref=&#038;iv_load_policy=1&#038;loop=0&#038;modestbranding=1&#038;rel=0&#038;fs=1&#038;playsinline=0&#038;autohide=2&#038;theme=dark&#038;color=red&#038;controls=1&#038;\" class=\"__youtube_prefs__ epyt-facade epyt-is-override  no-lazyload\" data-epautoplay=\"1\" ><img decoding=\"async\" data-spai-excluded=\"true\" class=\"epyt-facade-poster skip-lazy\" loading=\"lazy\"  alt=\"YouTube player\"  src=\"https:\/\/i0.wp.com\/i.ytimg.com\/vi\/Gsz_GMzoWgY\/maxresdefault.jpg?ssl=1\"  data-recalc-dims=\"1\" \/><button class=\"epyt-facade-play\" aria-label=\"Play\"><svg data-no-lazy=\"1\" height=\"100%\" version=\"1.1\" viewBox=\"0 0 68 48\" width=\"100%\"><path class=\"ytp-large-play-button-bg\" d=\"M66.52,7.74c-0.78-2.93-2.49-5.41-5.42-6.19C55.79,.13,34,0,34,0S12.21,.13,6.9,1.55 C3.97,2.33,2.27,4.81,1.48,7.74C0.06,13.05,0,24,0,24s0.06,10.95,1.48,16.26c0.78,2.93,2.49,5.41,5.42,6.19 C12.21,47.87,34,48,34,48s21.79-0.13,27.1-1.55c2.93-0.78,4.64-3.26,5.42-6.19C67.94,34.95,68,24,68,24S67.94,13.05,66.52,7.74z\" fill=\"#f00\"><\/path><path d=\"M 45,24 27,14 27,34\" fill=\"#fff\"><\/path><\/svg><\/button><\/div><\/div>\n<\/div><figcaption class=\"wp-element-caption\">Recording of Presentation<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"378\" height=\"317\" data-id=\"642\" src=\"https:\/\/i0.wp.com\/washingtonengineer.org\/wp-content\/uploads\/2023\/05\/wspe-biomed-imager.jpg?resize=378%2C317&#038;ssl=1\" alt=\"Biomedical imager\" class=\"wp-image-642\" srcset=\"https:\/\/i0.wp.com\/washingtonengineer.org\/wp-content\/uploads\/2023\/05\/wspe-biomed-imager.jpg?w=378&amp;ssl=1 378w, https:\/\/i0.wp.com\/washingtonengineer.org\/wp-content\/uploads\/2023\/05\/wspe-biomed-imager.jpg?resize=300%2C252&amp;ssl=1 300w\" sizes=\"(max-width: 378px) 100vw, 378px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"384\" height=\"406\" data-id=\"641\" src=\"https:\/\/i0.wp.com\/washingtonengineer.org\/wp-content\/uploads\/2023\/05\/wspe-biomed-brain.jpg?resize=384%2C406&#038;ssl=1\" alt=\"Biomedical Imaged Brain\" class=\"wp-image-641\" srcset=\"https:\/\/i0.wp.com\/washingtonengineer.org\/wp-content\/uploads\/2023\/05\/wspe-biomed-brain.jpg?w=384&amp;ssl=1 384w, https:\/\/i0.wp.com\/washingtonengineer.org\/wp-content\/uploads\/2023\/05\/wspe-biomed-brain.jpg?resize=284%2C300&amp;ssl=1 284w\" sizes=\"(max-width: 384px) 100vw, 384px\" data-recalc-dims=\"1\" \/><\/figure>\n<\/figure>\n\n\n\n<p>Critical treatment decisions for cancer patients are based on what pathologists observe in these limited 2D tissue sections, which often represent only 1% or less of the biopsied specimens. In order to improve clinical decisions and patient outcomes, a novel technological approach is needed that offers significant advantages over traditional \u201cgold-standard\u201d histopathology in terms of accuracy and throughput.<\/p>\n\n\n\n<p>We have developed an open-top light-sheet (OTLS) microscopy platform for slide-free 3D pathology of large clinical specimens, enabling whole biopsies and surgical specimens to be non-destructively imaged <em>in toto<\/em>.<\/p>\n\n\n\n<p>Using machine-learning techniques, we are quantifying 3D spatial and molecular biomarkers for prognosticating patient outcomes (i.e. distinguishing between indolent vs. lethal disease) and for predicting treatment response. 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